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T-box transcription factors and their roles in regulatory hierarchies in the developing heart

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posted on 2023-05-22, 23:44 authored by Fiona StennardFiona Stennard, Harvey, RP
T-box transcription factors are important players in the molecular circuitry that generates lineage diversity and form in the developing embryo. At least seven family members are expressed in the developing mammalian heart, and the human T-box genes TBX1 and TBX5 are mutated in cardiac congenital anomaly syndromes. Here, we review T-box gene function during mammalian heart development in the light of new insights into heart morphogenesis. We see for the first time how hierarchies of transcriptional activation and repression involving multiple T-box factors play out in three-dimensional space to establish the cardiac progenitors fields, to define their subservient lineages, and to generate heart form and function.

History

Publication title

Development (Cambridge)

Volume

132

Issue

22

Pagination

4897-910

ISSN

0950-1991

Department/School

Menzies Institute for Medical Research

Publisher

Company Of Biologists Ltd

Place of publication

Bidder Building Cambridge Commercial Park Cowley Rd, Cambridge, England, Cambs, Cb4 4Dl

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Copyright the Authors

Repository Status

  • Open

Socio-economic Objectives

Expanding knowledge in the biological sciences

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