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Graded ephrin-A2 expression in the developing hamster superior colliculus


Lukehurst, SS and King, CE and Beazley, LD and Tay, DKC and So, K-F and Rodger, J, Graded ephrin-A2 expression in the developing hamster superior colliculus, Experimental Brain Research, 173 pp. 546-552. ISSN 0014-4819 (2006) [Refereed Article]

Copyright Statement

2006 Springer-Verlag

DOI: doi:10.1007/s00221-006-0615-3


During development, ephrin gradients guide retinal ganglion cell axons to their appropriate topographic locations in the superior colliculus (SC). Expression of ephrin-A2, assessed immunohistochemically in the developing hamster SC, revealed a rostrallow to caudalhigh gradient that is most prominent at postnatal days (P)4 and P7 when topography is established. Double-labelling immunohistochemistry for ephrin-A2 and cell speciWc markers revealed that ephrin-A2 is expressed exclusively by a subset of neurons. The expression pattern has implications for mechanisms underlying establishment of topography during development and following injury.

Item Details

Item Type:Refereed Article
Keywords:Eph, ephrin, developing hamster, superior colliculus
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurology and neuromuscular diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:King, CE (Dr Carolyn King)
ID Code:99052
Year Published:2006
Web of Science® Times Cited:4
Deposited By:Health Sciences B
Deposited On:2015-03-11
Last Modified:2015-04-21

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