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Opic Nerve Regeneration: Molecular Pre-Requisites and the Role of Training
chapter
posted on 2023-05-22, 15:44 authored by Beazley, LD, Rodger, J, Carolyn KingCarolyn King, Bartlett, CA, Taylor, AL, Dunlop, SAThe vertebrate visual system is a valuable model for examining recovery after injury to the central nervous system (CNS). It is a relatively “simple” part of the CNS having one major class of projection neuron, the retinal ganglion cells (RGCs), which make topographic connections within well defined visual nuclei, thus recreating visual space within the brain. Topographic maps can be readily assessed electrophysiologically and anatomically and are a critical template for useful visually guided behaviour which can be examined behaviourally. Furthermore, the optic nerve is accessible, an extra-foramenal crush injury severing all RGC axons but leaving the meningeal sheath intact as a conduit for regeneration and preventing gross axonal mis-routing. The procedure also leaves the blood supply to the eye patent, avoiding ischaemic-induced RGC death.
History
Publication title
Advances in Experimental Medicine and Biology. Retinal Degenerative Diseases.Volume
572Editors
J Hollyfield, RE Anderson & MM LaVailPagination
389-395ISBN
978-0-387-28464-4Department/School
School of NursingPublisher
SpringerPlace of publication
United StatesExtent
71Rights statement
Copyright 2006 Springer Science+Business Media, Inc.Repository Status
- Restricted