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Circulating biomarkers of diabetic retinopathy: a systematic review and meta-analysis


McAuley, AK and Sanfilippo, PG and Connell, PP and Wang, JJ and Dirani, M and Lamoureux, E and Hewitt, A, Circulating biomarkers of diabetic retinopathy: a systematic review and meta-analysis, Diabetes Management, 2, (2) pp. 157-169. ISSN 1758-1907 (2012) [Refereed Article]

DOI: doi:10.2217/dmt.12.4


Approximately a third of adults with diabetes have diabetic retinopathy (DR), a potentially blinding eye disease. This study aimed to summarize known biomarkers associated with DR and investigate their potential roles in retinopathy phenotype. All available data from studies analyzing human peripheral blood samples were extracted for meta-analysis. Pathway analysis was subsequently performed on the biomarkers found to be associated with DR. We identified a significant difference in circulating levels of: soluble ICAM-1 (p < 0.0001), asymmetric dimethylarginine (p < 0.001), adrenomedullin (p = 0.04), soluble E-selectin (p = 0.0017), soluble VCAM-1 (p < 0.001) and von Willebrand factor (p = 0.0004), between patients with various stages of DR and patients with diabetes but no retinopathy. Several distinct biomarkers were consistently found to be associated with DR. Many of these biomarkers are known to function in pathways that promote leukocyte adhesion and transmigration into cells, presumably contributing to the characteristic vascular dysfunction observed in DR.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Hewitt, A (Professor Alex Hewitt)
ID Code:95376
Year Published:2012
Deposited By:Medicine
Deposited On:2014-09-30
Last Modified:2014-09-30

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