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Twins Eye Study in Tasmania (TEST): Rationale and methodology to recruit and examine twins


Mackey, DA and Mackinnon, JR and Brown, SA and Kearns, LS and Ruddle, JB and Sanfilippo, PG and Sun, C and Hammond, CJ and Young, TL and Martin, NG and Hewitt, A, Twins Eye Study in Tasmania (TEST): Rationale and methodology to recruit and examine twins, Twin Research and Human Genetics, 12, (5) pp. 441-454. ISSN 1832-4274 (2009) [Refereed Article]

DOI: doi:10.1375/twin.12.5.441


Visual impairment is a leading cause of morbidity and poor quality of life in our community. Unravelling the mechanisms underpinning important blinding diseases could allow preventative or curative steps to be implemented. Twin siblings provide a unique opportunity in biology to discover genes associated with numerous eye diseases and ocular biometry. Twins are particularly useful for quantitative trait analysis through genome-wide association and linkage studies. Although many studies involving twins rely on twin registries, we present our approach to the Twins Eye Study in Tasmania to provide insight into possible recruitment strategies, expected participation rates and potential examination strategies that can be considered by other researchers for similar studies. Five separate avenues for cohort recruitment were adopted: (1) piggy-backing existing studies where twins had been recruited, (2) utilizing the national twin registry, (3) word-of-mouth and local media publicity, (4) directly approaching schools, and finally (5) collaborating with other research groups studying twins.

Item Details

Item Type:Refereed Article
Keywords:Genetics; Genome-wide association; Glaucoma; Myopia; Ophthalmology
Research Division:Biomedical and Clinical Sciences
Research Group:Ophthalmology and optometry
Research Field:Ophthalmology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Mackey, DA (Professor David Mackey)
UTAS Author:Hewitt, A (Professor Alex Hewitt)
ID Code:95262
Year Published:2009
Web of Science® Times Cited:32
Deposited By:Medicine
Deposited On:2014-09-29
Last Modified:2015-02-05

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