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Aortic reservoir pressure corresponds to cyclic changes in aortic volume: physiological validation in humans
journal contribution
posted on 2023-05-18, 01:41 authored by Martin SchultzMartin Schultz, Davies, JE, Ashutosh HardikarAshutosh Hardikar, Pitt, S, Moraldo, M, Dhutia, N, Hughes, AD, James SharmanJames SharmanOBJECTIVE: Aortic reservoir pressure indices independently predict cardiovascular events and mortality. Despite this, there has never been a study in humans to determine whether the theoretical principles of the mathematically derived aortic reservoir pressure (RPderived) and excess pressure (XPderived) model have a real physiological basis. This study aimed to directly measure the aortic reservoir (ARdirect; by cyclic change in aortic volume) and determine its relationship with RPderived, XPderived, and aortic blood pressure (BP). APPROACH AND RESULTS: Ascending aortic BP and Doppler flow velocity were recorded via intra-arterial wire in 10 men (aged 62±12 years) during coronary artery bypass surgery. Simultaneous ascending aortic transesophageal echocardiography was used to measure ARdirect. Published mathematical formulae were used to determine RPderived and XPderived. ARdirect was strongly and linearly related to RPderived during systole (r=0.988; P<0.001) and diastole (r=0.985; P<0.001). Peak cross-correlation (r=0.98) occurred at a phase lag of 0.004 s into the cardiac cycle, suggesting close temporal agreement between waveforms. The relationship between aortic BP and ARdirect was qualitatively similar to the cyclic relationship between aortic BP and RPderived, with peak cross-correlations occurring at identical phase lags (ARdirect versus aortic BP, r=0.96 at 0.06 s; RPderived versus aortic BP, r=0.98 at 0.06 s). CONCLUSIONS: RPderived is highly correlated with changes in proximal aortic volume, consistent with its physiological interpretation as corresponding to the instantaneous volume of blood stored in the aorta. Thus, aortic reservoir pressure should be considered in the interpretation of the central BP waveform.
History
Publication title
Arteriosclerosis, Thrombosis, and Vascular BiologyVolume
34Issue
7Pagination
1597-1603ISSN
1079-5642Department/School
Menzies Institute for Medical ResearchPublisher
Lippincott Williams & WilkinsPlace of publication
530 Walnut St, Philadelphia, USA, Pa, 19106-3621Rights statement
Copyright 2014 American Heart Association, Inc.Repository Status
- Restricted