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Metabolomics in hypertension
journal contribution
posted on 2023-05-18, 01:36 authored by Nikolic, SB, James SharmanJames Sharman, Adams, MJ, Edwards, LMHypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of hypertensive cases, the underlying cause of hypertension cannot be easily identified because of the heterogeneous, polygenic and multi-factorial nature of hypertension. Metabolomics is a relatively new field of research that has been used to evaluate metabolic perturbations associated with disease, identify disease biomarkers and to both assess and predict drug safety and efficacy. Metabolomics has been increasingly used to characterize risk factors for cardiovascular disease, including hypertension, and it appears to have significant potential for uncovering mechanisms of this complex disease. This review details the analytical techniques, pre-analytical steps and study designs used in metabolomics studies, as well as the emerging role for metabolomics in gaining mechanistic insights into the development of hypertension. Suggestions as to the future direction for metabolomics research in the field of hypertension are also proposed. © 2014 Wolters Kluwer Health | Lippincott Williams Wilkins.
History
Publication title
Journal of HypertensionVolume
32Issue
6Pagination
1159-1169ISSN
0263-6352Department/School
Menzies Institute for Medical ResearchPublisher
Lippincott Williams & WilkinsPlace of publication
530 Walnut St, Philadelphia, USA, Pa, 19106-3621Rights statement
Copyright 2014 Lippincott Williams & WilkinsRepository Status
- Restricted