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Alzheimer's disease-like impaired cognition in endothelial-specific megalin-null mice
journal contribution
posted on 2023-05-17, 23:22 authored by Dietrich, M, Antequera, D, Pascual, C, Castro, N, Bolos, M, Carro, EMegalin has been suggested to be involved in Alzheimer's disease (AD), mediating blood-brain barrier (BBB) transport of multiple ligands, including amyloid-β peptide (Aβ), but also neuroprotective factors. Because no transgenic model is currently available to study this concept, we have obtained transgenic mice blocking megalin expression at the BBB. These endothelial megalin deficient (EMD) mice developed increased anxiety behavior and impaired learning ability and recognition memory, similar to symptoms described in AD. Degenerating neurons were also observed in the cerebral cortex of EMD mice. In view of our findings we suggest that, in mice, megalin deficiency at the BBB leads to neurodegeneration.
History
Publication title
Journal of Alzheimer'S DiseaseVolume
39Issue
4Pagination
711-717ISSN
1387-2877Department/School
Menzies Institute for Medical ResearchPublisher
I O S PressPlace of publication
NetherlandsRepository Status
- Restricted