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Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia
journal contribution
posted on 2023-05-17, 22:50 authored by Holmes, NE, Turnidge, JD, Munckhof, WJ, Robinson, JO, Korman, TM, O'Sullivan, MVN, Anderson, TL, Roberts, SA, Warren, SJC, Gao, W, Johnson, PDR, Howden, BPWe reported an association between elevated vancomycin MIC and 30-day mortality in patients with Staphylococcus aureus bacteraemia (SAB), including patients with methicillin-susceptible S. aureus (MSSA) treated with flucloxacillin. A detailed analysis of comorbidities and disease severity scores in the same cohort of patients was performed to ascertain if unknown clinical parameters may have influenced these results. The association between elevated vancomycin MIC and 30-day mortality in SAB remained significant (p 0.001) on multivariable logistic regression analysis even when accounting for clinical factors. In addition, the association persisted when restricting analysis to patients with MSSA bacteraemia treated with flucloxacillin. This suggests that elevated vancomycin MIC is associated with but not causally linked to an organism factor that is responsible for increased mortality.
History
Publication title
Clinical Microbiology and InfectionVolume
19Issue
12Pagination
1163-1168ISSN
1198-743XDepartment/School
Tasmanian School of MedicinePublisher
Wiley-Blackwell PublishingPlace of publication
United KingdomRights statement
Copyright 2013 The Authors Clinical Microbiology and Infection Copyright 2013 European Society of Clinical Microbiology and Infectious DiseasesRepository Status
- Restricted