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Prognostic implication of preoperative behavior changes in patients with primary high-grade meningiomas


Vranic, A and Gilbert, F, Prognostic implication of preoperative behavior changes in patients with primary high-grade meningiomas, Scientific World Journal, 2014 Article 398295. ISSN 1537-744X (2014) [Refereed Article]


Copyright Statement

Copyright 2014 The Authors-This is an open access article distributed under the Creative Commons Attribution License, (CC BY-NC-ND 3.0 AU) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.1155/2014/398295


High-grade meningiomas are rare extra-axial tumors, frequently causing brain invasion and prominent brain edema. Patients harboring high-grade meningiomas occasionally present with behavior changes. Data about frequency and prognostic importance of preoperative behavior changes in patients with high-grade meningiomas is missing. 86 patients with primary high-grade meningiomas were analyzed. Statistical analysis was performed to determine correlation of preoperative behavior changes with tumor location, preoperative brain edema, tumor cleavability, tumor grade, Ki67 proliferation index, and microscopic brain invasion. Survival analysis was performed. 30 (34.9%) patients presented with preoperative behavior changes. These changes were more frequent with male patients (��= 0.066) and patients older than 55 years (��= 0.018). They correlated with frontal location (��= 0.013), tumor size (��= 0.023), microscopic brain invasion (��=0.015), and brain edema (��= 0.006). Preoperative behavior changes did not correlate with duration of symptoms, tumor cleavability, tumor malignancy grade, and Ki67 proliferation index. They were not significantly related to overall survival or recurrence-free survival of patients with primary high-grade meningiomas. Preoperative behavior changes are frequent in patients harboring primary high-grade meningiomas. They correlate with tumor size, microscopic brain invasion, and brain edema. Preoperative behavior changes do not predict prognosis in patients with primary high-grade meningiomas.

Item Details

Item Type:Refereed Article
Keywords:Personality Changes, Neuroethics, Bioethics, Brain Intervention, Prognostics, High-Grade Meningiomas
Research Division:Philosophy and Religious Studies
Research Group:Applied ethics
Research Field:Ethical use of new technology
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in philosophy and religious studies
UTAS Author:Gilbert, F (Dr Frederic Gilbert)
ID Code:89407
Year Published:2014
Web of Science® Times Cited:11
Deposited By:School of Humanities
Deposited On:2014-03-04
Last Modified:2018-02-13
Downloads:349 View Download Statistics

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