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Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats


Pirie, AD and Davies, NW and Ahuja, KDK and Adams, MJ and Shing, CM and Narkowicz, C and Jacobson, GA and Geraghty, DP, Hypolipidaemic effect of crude extract from Carpobrotus rossii (pigface) in healthy rats, Food and Chemical Toxicology, 66 pp. 134-139. ISSN 0278-6915 (2014) [Refereed Article]

Copyright Statement

Copyright 2014 Elsevier

DOI: doi:10.1016/j.fct.2014.01.034


Carpobrotus rossii (CR) was used by the Aboriginal population and early European settlers both as a food and therapeutic agent. Based on the presence of flavonoids in CR and results from our previous in vitro investigations, this study aimed to determine whether consumption of CR crude leaf extract: (a) affected lipoprotein profile, resting glucose, systolic blood pressure and vascular function, and (b) produced toxic effects (haematological measures, organ weight) in healthy rats. Male Hooded-Wistar rats (∼230 g) were supplemented for 4 weeks with CR extract in their drinking water (35 mg/kg body weight daily). CR extract produced a significant decrease (18%, p = 0.033) in atherogenic lipoproteins (but not high density lipoprotein). CR supplemented animals showed no signs of haematological toxicity and body and organ weight, daily fluid and food consumption and in vitro vascular responsiveness were similar for both groups. CR also increased (40%, p = 0.049) the renal concentration of 3-hydroxy-3-methylglutaric acid (HMG), consistent with HMG-containing CR flavonoids being bioavailable, and therefore possessing the potential to interfere with cholesterol synthesis pathways. CR extract appears to be safe to ingest and may reduce cardiovascular risk.

Item Details

Item Type:Refereed Article
Keywords:cardiovascular, lipid, toxicology, Carpobrotus spp., polyphenolic, traditional medicine, flavonoid, flavonol
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Basic pharmacology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Pirie, AD (Mr Adam Pirie)
UTAS Author:Davies, NW (Associate Professor Noel Davies)
UTAS Author:Ahuja, KDK (Dr Kiran Ahuja)
UTAS Author:Adams, MJ (Dr Murray Adams)
UTAS Author:Shing, CM (Dr Cecilia Kitic)
UTAS Author:Narkowicz, C (Dr Christian Narkowicz)
UTAS Author:Jacobson, GA (Associate Professor Glenn Jacobson)
UTAS Author:Geraghty, DP (Professor Dominic Geraghty)
ID Code:88232
Year Published:2014
Web of Science® Times Cited:4
Deposited By:Health Sciences A
Deposited On:2014-01-21
Last Modified:2018-02-08

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