University of Tasmania
Browse

File(s) not publicly available

Western style diet impairs entrance of blood-borne insulin-like growth factor-1 into the brain

journal contribution
posted on 2023-05-17, 20:37 authored by Dietrich, MO, Muller, A, Bolos, M, Carro, E, Perry, ML, Portela, LV, Souza, DO, Torres-Aleman, I
It is increasingly recognized that life-style factors, such as physical exercise or diet influence brain health. In the present work we analyzed the effect of a western-style diet ("cafeteria diet") on the entrance to the brain of circulating IGF-1, a neuroprotective agent that has been related to different neurodegenerative diseases. Rats under a cafeteria diet showed reduced passage of systemic IGF-1 across the choroid plexus, a main site of IGF-1 entrance into the brain through the cerebrospinal fluid. Furthermore, the IGF-1 receptor at the choroid plexus of rats fed with a cafeteria diet showed enhanced sensitivity toward IGF-1 while receptor levels remained unchanged. Examination of possible mechanisms underlying reduced entrance of systemic IGF-1 to the brain showed that triglycerides that increased in blood after a cafeteria diet, diminished the passage of IGF-1 across choroid plexus epithelia. This effect of triglycerides was achieved by altering the interaction of IGF-1 with megalin, a choroid plexus transporter involved in transcytosis of IGF-1 from the circulation into the brain. Reduced brain entrance of circulating IGF-1 elicited by a western-style diet suggests that the higher incidence of brain diseases related to inadequate diets is due in part to diminished neurotrophic support.

History

Publication title

Neuromolecular Medicine

Volume

9

Issue

4

Pagination

324-330

ISSN

1535-1084

Department/School

Menzies Institute for Medical Research

Publisher

Humana Press Inc

Place of publication

999 Riverview Drive Suite 208, Totowa, USA, Nj, 07512

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the biological sciences

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC