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Neurogenic effects of β-amyloid in the choroid plexus epithelial cells in Alzheimer's disease

journal contribution
posted on 2023-05-17, 20:36 authored by Bolos, M, Spuch, C, Ordonez-Gutierrez, L, Wandosell, F, Ferrer, I, Carro, E
β-amyloid (Aβ) can promote neurogenesis, both in vitro and in vivo, by inducing neural progenitor cells to differentiate into neurons. The choroid plexus in Alzheimer's disease (AD) is burdened with amyloid deposits and hosts neuronal progenitor cells. However, neurogenesis in this brain tissue is not firmly established. To investigate this issue further, we examined the effect of Aβ on the neuronal differentiation of choroid plexus epithelial cells in several experimental models of AD. Here we show that Aβ regulates neurogenesis in vitro in cultured choroid plexus epithelial cells as well as in vivo in the choroid plexus of APP/Ps1 mice. Treatment with oligomeric Aβ increased proliferation and differentiation of neuronal progenitor cells in cultured choroid plexus epithelial cells, but decreased survival of newly born neurons. These Aβ-induced neurogenic effects were also observed in choroid plexus of APP/PS1 mice, and detected also in autopsy tissue from AD patients. Analysis of signaling pathways revealed that pre-treating the choroid plexus epithelial cells with specific inhibitors of TyrK or MAPK diminished Aβ-induced neuronal proliferation. Taken together, our results support a role of Aβ in proliferation and differentiation in the choroid plexus epithelial cells in Alzheimer's disease.

History

Publication title

Cellular and Molecular Life Sciences

Volume

70

Issue

15

Pagination

2787-2797

ISSN

1420-682X

Department/School

Menzies Institute for Medical Research

Publisher

Birkhauser Verlag Ag

Place of publication

Viadukstrasse 40-44, Po Box 133, Basel, Switzerland, Ch-4010

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the biological sciences

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