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Plasticity of Recurrent L2/3 Inhibition and Gamma Oscillations by Whisker Experience


Shao, YR and Isett, BR and Miyashita, T and Chung, J and Pourzia, O and Gasperini, RJ and Feldman, DE, Plasticity of Recurrent L2/3 Inhibition and Gamma Oscillations by Whisker Experience, Neuron, 80, (1) pp. 210-222. ISSN 0896-6273 (2013) [Refereed Article]

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Copyright 2013 Elsevier Inc.

DOI: doi:10.1016/j.neuron.2013.07.026


Local recurrent networks in neocortex are critical nodes for sensory processing, but their regulation by experience is much less understood than for long-distance (translaminar or cross-columnar) projections. We studied local L2/3 recurrent networks in rat somatosensory cortex during deprivation-induced whisker map plasticity, by expressing channelrhodopsin-2 (ChR2) in L2/3 pyramidal cells and measuring light-evoked synaptic currents in exvivo S1 slices. In columns with intact whiskers, brief light impulses evoked recurrent excitation and supralinear inhibition. Deprived columns showed modestly reduced excitation and profoundly reduced inhibition, providing a circuit locus for disinhibition of whisker-evoked responses observed in L2/3 invivo. Slower light ramps elicited sustained gamma frequency oscillations, which were nearly abolished in deprived columns. Reduction in gamma power was also observed in spontaneous LFP oscillations in L2/3 of deprived columns invivo. Thus, L2/3 recurrent networks are a powerful site for homeostatic modulation of excitation-inhibition balance and regulation of gamma oscillations. © 2013 Elsevier Inc.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Cellular nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Gasperini, RJ (Dr Rob Gasperini)
ID Code:86710
Year Published:2013
Web of Science® Times Cited:24
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-10-15
Last Modified:2017-11-06

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