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Vanilloid Like Agents: Potential Therapeutic Targeting of Platelets?


Adams, MJ and Almaghrabi, S and Ahuja, KDK and Geraghty, DP, Vanilloid Like Agents: Potential Therapeutic Targeting of Platelets?, Drug Development Research, 74 pp. 450-459. ISSN 1098-2299 (2013) [Substantial Review]

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DOI: doi:10.1002/ddr.21102


Capsaicinoids are the ‘hot’ compounds in placental tissues of Capsicum fruits that are responsible for capsicum’s pungency. Capsaicinoids belong to the broader class of vanilloids that activate the non-selective cation channel, transient receptor potential vanilloid-1 (TRPV1). Endogenous vanilloids include arachidonic acid derivatives that have different affinities for TRPV1 and are increasingly recognized as an important group of signaling molecules affecting tissue injury, pain and inflammation. Furthermore, some endogenous vanilloids have high affinity for cannabinoid receptors (CB1 and CB2), which are present in platelets. The most well-known and widely studied plant-derived vanilloid, capsaicin, is reported to have anti-platelet properties but the mechanism of action is uncertain. This article will briefly review the mechanisms involved in platelet activation and aggregation, discuss the properties of vanilloids and their receptor, TRPV1, and discuss whether the effects of vanilloids, and particularly capsaicinoids, on platelets may be exploited for therapeutic benefit.

Item Details

Item Type:Substantial Review
Keywords:Platelets, vanilloids, capsaicinoids, transient receptor potential vanilloid-, cardiovascular disease
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Haematology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Diagnosis of human diseases and conditions
UTAS Author:Adams, MJ (Dr Murray Adams)
UTAS Author:Almaghrabi, S (Ms Safa Almaghrabi)
UTAS Author:Ahuja, KDK (Dr Kiran Ahuja)
UTAS Author:Geraghty, DP (Professor Dominic Geraghty)
ID Code:86588
Year Published:2013
Deposited By:Health Sciences A
Deposited On:2013-09-29
Last Modified:2014-06-05

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