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Psychosocial factors in people with chronic kidney disease prior to renal replacement therapy


McKercher, C and Sanderson, K and Jose, MD, Psychosocial factors in people with chronic kidney disease prior to renal replacement therapy, Nephrology, 18, (9) pp. 585-591. ISSN 1320-5358 (2013) [Refereed Article]

Copyright Statement

Copyright 2013 The Authors Nephrology copyright 2013 Asian Pacific Society of Nephrology

DOI: doi:10.1111/nep.12138


Increasing evidence implicates psychosocial factors including depression, anxiety, perceived social support and health-related quality of life in the pathophysiology of various chronic diseases. Research examining the psychosocial aspects of kidney disease has focussed predominantly on depressive disorders in dialysis patients where they are independently associated with increased risk of mortality and poor health-related quality of life. In contrast, studies examining the influence of psychosocial factors in people with chronic kidney disease (CKD) prior to the initiation of renal replacement therapy are sparse. Limited data indicate that clinical depression and depressive symptoms are common and may independently predict progression to dialysis, hospitalization and death. In contrast, the influence of anxiety disorders, lower perceived social support and impaired health-related quality of life on the clinical course of CKD have received little attention. Large-scale prospective cohort studies are needed to clarify the burden and prognostic impact of these factors in this vulnerable population. Given the escalating burden of CKD worldwide examining the role of these potentially modifiable risk factors is crucial. Identifying and implementing targeted interventions in order to prevent or delay the progression of CKD and improve quality of life will be a major challenge.

Item Details

Item Type:Refereed Article
Keywords:chronic kidney disease (CKD), epidemiology, psychology/psychiatry
Research Division:Biomedical and Clinical Sciences
Research Group:Clinical sciences
Research Field:Nephrology and urology
Objective Division:Health
Objective Group:Public health (excl. specific population health)
Objective Field:Mental health
UTAS Author:McKercher, C (Dr Charlotte McKercher)
UTAS Author:Sanderson, K (Associate Professor Kristy Sanderson)
UTAS Author:Jose, MD (Professor Matthew Jose)
ID Code:86225
Year Published:2013
Web of Science® Times Cited:19
Deposited By:Menzies Institute for Medical Research
Deposited On:2013-08-29
Last Modified:2017-11-02
Downloads:1 View Download Statistics

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