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Recent advance in understanding inflammation and remodelling in the airways in COPD


Sohal, SS and Ward, C and Danial, W and Wood-Baker, R and Walters, EH, Recent advance in understanding inflammation and remodelling in the airways in COPD, Expert Review of Respiratory Medicine, 7, (3) pp. 275-288. ISSN 1747-6348 (2013) [Substantial Review]

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DOI: doi:10.1586/ers.13.26


The authors have reviewed the current literature on airway inflammation and remodeling in smoking-related chronic obstructive pulmonary disease (COPD). Detailed data on airway remodeling in COPD are especially sparse and how these changes lead to decline in lung function is not well understood. Small airway fibrosis and obliteration are likely to be the main contributors to physiological airway dysfunction and occur earlier than any subsequent development of emphysema. One potential mechanism contributing to small airway fibrosis/obliteration and change in extracellular matrix is epithelial-mesenchymal transition. When associated with angiogenesis (so-called epithelial-mesenchymal transition type 3) it may well also be the link with the development of cancer, which is closely associated with COPD, predominantly in large airways. The authors have focused on our recent publications in these areas. Further investigations teasing out these mechanisms will help improve our understanding of key airway disease processes in COPD, which may have major therapeutic implications.

Item Details

Item Type:Substantial Review
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Respiratory diseases
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sohal, SS (Dr Sukhwinder Sohal)
UTAS Author:Ward, C (Miss Carly Ward)
UTAS Author:Danial, W (Dr Wan Noor)
UTAS Author:Wood-Baker, R (Professor Richard Wood-Baker)
UTAS Author:Walters, EH (Professor Haydn Walters)
ID Code:84015
Year Published:2013
Web of Science® Times Cited:66
Deposited By:Medicine
Deposited On:2013-04-11
Last Modified:2013-06-11

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