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81544 - The impact of statins on psychological wellbeing.pdf (282.34 kB)

The impact of statins on psychological wellbeing: a systematic review and meta-analysis

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posted on 2023-05-17, 15:01 authored by O'Neil, A, Sanna, L, Redlich, C, Kristy Sanderson, Jacka, F, Williams, LJ, Pasco, JA, Berk, M

Background: Cholesterol-lowering medications such as statins have anti-inflammatory and antioxidant properties, which may be beneficial for treating depression and improving mood. However, evidence regarding their effects remains inconsistent, with some studies reporting links to mood disturbances. We aimed to conduct a metaanalysis to determine the impact of statins on psychological wellbeing of individuals with or without hypercholesterolemia.

Methods: Articles were identified using medical, health, psychiatric and social science databases, evaluated for quality, and data were synthesized and analyzed in RevMan-5 software using a random effects model.

Results: The 7 randomized controlled trials included in the analysis represented 2,105 participants. A test for overall effect demonstrated no statistically significant differences in psychological wellbeing between participants receiving statins or a placebo (standardized mean difference (SMD) = -0.08, 95% CI -0.29 to 0.12; P = 0.42). Sensitivity analyses were conducted to separately analyze depression (n = 5) and mood (n = 2) outcomes; statins were associated with statistically significant improvements in mood scores (SMD = -0.43, 95% CI -0.61 to -0.24).

Conclusions: Our findings refute evidence of negative effects of statins on psychological outcomes, providing some support for mood-related benefits. Future studies could examine the effects of statins in depressed populations.

Funding

Australian Research Council

History

Publication title

BMC Medicine

Volume

10

Article number

154

Number

154

Pagination

1-9

ISSN

1741-7015

Department/School

Menzies Institute for Medical Research

Publisher

BioMed Central Ltd.

Place of publication

United Kingdom

Rights statement

Licensed under Creative Commons Attribution 2.0 Generic (CC BY 2.0) http://creativecommons.org/licenses/by/2.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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