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Evaluation of the Innovance D-Dimer assay for the diagnosis of disseminated intravascular coagulopathy in different clinical settings
journal contribution
posted on 2023-05-17, 13:16 authored by Alhossain Khalafallah, Jarvis, C, Michael MorseMichael Morse, Al-Barazan, A-M, Stewart, P, Bates, G, Hayes, R, Iain RobertsonIain Robertson, Seaton, D, Brain, TDisseminated intravascular coagulopathy (DIC) is a serious disease with fatal consequences. We prospectively analyzed Innovance d-dimer immunoturbidimetric assay in 68 patients diagnosed with DIC on the background of malignancy (22), severe infection (20), or multitrauma (26) at a single institution between January 2010 and January 2011. Median age was 61 years (range 20-89). All patients were assessed according to the International Society of Thrombosis and Haemostasis (ISTH) DIC score. Applying a threshold of Innovance D-dimer of 10 mg/L fibrinogen equivalent unit (normal <0.5) was correlated with the highest sensitivity in malignancy (86%) and trauma/surgery (80%) compared to 54% in infection. The specificity remained high at 97% in infection, 81% in trauma and 77% in malignancy with a negative predictive value of 97% in trauma and malignancy, and 88% in infection. Our data suggest that Innovance D-dimer is a useful and simple tool that enhances the ISTH DIC diagnostic criteria. Further studies to confirm these findings are warranted.
History
Publication title
Clinical and Applied Thrombosis - HemostasisVolume
20Pagination
91-97ISSN
1076-0296Department/School
School of Health SciencesPublisher
Westminster Publ IncPlace of publication
708 Glen Cove Ave, Glen Head, USA, Ny, 11545Rights statement
Copyright 2012 Sage PublicationsRepository Status
- Restricted