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Sex differences in long-term outcomes after stroke: functional outcomes, handicap, and quality of life
journal contribution
posted on 2023-05-17, 12:46 authored by Seana GallSeana Gall, Pham, TL, Martin, K, Christopher BlizzardChristopher Blizzard, Srikanth, VThere has been recent interest in sex differences in stroke with a focus on the first 3 months after stroke. We recently reported that females had more severe strokes, higher short-term mortality, and different management in comparison to males. This was explained by females' greater age and prevalence of comorbidities at stroke onset, findings supported by a recent review. Others have suggested that being female is a risk factor for poorer outcomes in the acute period independent of age and other covariates, raising the possibility of a sex bias in the diagnosis or treatment of stroke in females. Alternatively, biological differences between the sexes could influence outcome. For example, differences in muscle strength could explain worse functional outcomes in females. Despite this recent interest, there has been little discussion of sex differences with regard to outcome in the longer term after stroke. This review addresses this gap, exploring sex differences in (1) functional outcomes, also known as “activity limitations” and historically as “disability”; (2) handicap, also known as “restriction of participation”; and (3) quality of life.
Funding
Financial Markets Foundation for Children
History
Publication title
StrokeVolume
43Issue
7Pagination
1982-1987ISSN
0039-2499Department/School
Menzies Institute for Medical ResearchPublisher
Lippincott Williams & WilkinsPlace of publication
530 Walnut St, Philadelphia, USA, Pa, 19106-3621Rights statement
Copyright 2012 American Heart Association, Inc.Repository Status
- Restricted