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D-Dimer levels at different stages of pregnancy in Australian women: A single centre study using two different immunoturbidimetric assays

journal contribution
posted on 2023-05-17, 12:24 authored by Alhossain Khalafallah, Michael MorseMichael Morse, Al-Barzan, AM, Adams, M, Dennis, A, Bates, G, Iain RobertsonIain Robertson, Seaton, D, Brain, T

Background: To date there is minimal data available on D-Dimer levels at different stages of pregnancy.

Patients and methods: We prospectively measured D-Dimer levels in 632 consecutive pregnant women from March 2007 to January 2009. The median age of the participants was 31years (range; 18-42) with a median weight of 78 kilograms (range; 46-137). All subjects were investigated during each trimester with two different immunoturbidimetric assays; D-Dimer PLUS and INNOVANCE D-Dimer. D-Dimer levels were determined using a Sysmex® CA 1500 analyser.

Results: Our data demonstrate that D-Dimer levels in pregnancy show different patterns of rise within the first trimester, depending on the assay used; D-Dimer PLUS = 0.88 (SD: mean ratio), INNOVANCE D-Dimer = 0.72 (SD: mean ratio). Furthermore, the rise in mean results was greater for the INNOVANCE D-Dimer assay compared to the D-Dimer PLUS assay as shown by the ratio of third to first trimester results of 3.68 and 1.96 respectively. Both D-Dimer assays demonstrated moderate levels of intra-subject variability, with overall mean CVs of 16.5% (D-Dimer PLUS) and 16.9% (INNOVANCE D-Dimer). Furthermore, we studied the association between D-Dimer levels and occurrence of diseases of pregnancy. For both assays, there was no consistently interpretable evidence of an association between raised mean D-Dimer levels or rising D-Dimer levels and any of the diseases or conditions associated with pregnancy.

Conclusion: Our data suggest that the INNOVANCE D-Dimer assay increases significantly with the advancement of pregnancy, and is more sensitive than D-Dimer PLUS assay in the pregnant population.

History

Publication title

Thrombosis Research

Volume

130

Pagination

e171-e177

ISSN

0049-3848

Department/School

School of Health Sciences

Publisher

Pergamon-Elsevier Science Ltd

Place of publication

The Boulevard, Langford Lane, Kidlington, Oxford, England, Ox5 1Gb

Rights statement

Copyright 2012 Elsevier Ltd.

Repository Status

  • Restricted

Socio-economic Objectives

Diagnosis of human diseases and conditions

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