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Neuroprotection and regeneration by extracellular metallothionein via lipoprotein-receptor-related proteins

journal contribution
posted on 2023-05-17, 11:39 authored by Adrian WestAdrian West, Jacqueline LeungJacqueline Leung, Chung, RS
Metallothionein has a well-documented pro- tective and proregenerative effect in the mammalian brain, particularly following physical trauma and ischemia or during the onset of neurodegenerative disease. A range of mechanisms have been established for this, including metallothionein�s metal binding properties and its ability to scavenge free radicals. In recent years it has become apparent that metallothionein is present in the extracellular compartment of the central nervous system and that it can interact with cell surface receptors of the lipoprotein- receptor-related protein family, including lipoprotein- receptor-related protein 1 (LRP1) and megalin. These interactions activate intracellular pathways which are consistent with many of the observed effects of metallo- thionein in the central nervous system, including its effects on neurons, glial cells, and cells of the immune system. The evidence describing the release, receptor interactions, and subsequent physiological consequences of metallothi- onein is discussed in this review.

History

Publication title

Journal of Biological Inorganic Chemistry

Volume

16

Issue

7

Pagination

1115-1122

ISSN

0949-8257

Department/School

Menzies Institute for Medical Research

Publisher

Springer

Place of publication

Germany

Rights statement

Copyright 2011 SBIC

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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