University of Tasmania
Browse

File(s) under permanent embargo

Salicylhydroxamic Acid Inhibits the Growth of Candida albicans

journal contribution
posted on 2023-05-17, 10:18 authored by Pang, SM, Stephen TristramStephen Tristram, Brown, S
Candida spp. are common and aggressive pathogens. Because of the growing resistance of Candida spp. to current antifungals, novel targets, found in Candida spp. but not in humans or other flora, have to be identified. The alternative oxidase (AOX) is one such possibility. This enzyme is insensitive to cyanide, but is sensitive to compounds such as salicylhydroxamic acid (SHAM), disulfiram and n-alkyl gallates. The growth Candida albicans was inhibited by SHAM (Ki = 9-15 mM) and cyanide (Ki = 2-4 mM), albeit to differing extents. The rate of O2 uptake was inhibited by less than 10% by 25 mM SHAM and by about 90% by 250 ìM KCN. Although SHAM substantially inhibited the growth of C. albicans, it is unlikely that the inhibition of AOX was the cause. Salicylhydroxamic acid is used therapeutically in the treatment of urinary tract infections and urolithiasis, but it also has some potential in the treatment of C. albicans infection.

History

Publication title

International Journal of Biological and Life Sciences

Volume

7

Pagination

40-46

ISSN

2073-0527

Department/School

School of Health Sciences

Publisher

World Academy of Sciences

Place of publication

USA

Rights statement

Copyright 2011 World Academy of Science, Engineering and Technology

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC