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Salicylhydroxamic Acid Inhibits the Growth of Candida albicans
journal contribution
posted on 2023-05-17, 10:18 authored by Pang, SM, Stephen TristramStephen Tristram, Brown, SCandida spp. are common and aggressive pathogens. Because of the growing resistance of Candida spp. to current antifungals, novel targets, found in Candida spp. but not in humans or other flora, have to be identified. The alternative oxidase (AOX) is one such possibility. This enzyme is insensitive to cyanide, but is sensitive to compounds such as salicylhydroxamic acid (SHAM), disulfiram and n-alkyl gallates. The growth Candida albicans was inhibited by SHAM (Ki = 9-15 mM) and cyanide (Ki = 2-4 mM), albeit to differing extents. The rate of O2 uptake was inhibited by less than 10% by 25 mM SHAM and by about 90% by 250 ìM KCN. Although SHAM substantially inhibited the growth of C. albicans, it is unlikely that the inhibition of AOX was the cause. Salicylhydroxamic acid is used therapeutically in the treatment of urinary tract infections and urolithiasis, but it also has some potential in the treatment of C. albicans infection.
History
Publication title
International Journal of Biological and Life SciencesVolume
7Pagination
40-46ISSN
2073-0527Department/School
School of Health SciencesPublisher
World Academy of SciencesPlace of publication
USARights statement
Copyright 2011 World Academy of Science, Engineering and TechnologyRepository Status
- Restricted