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Omari et al MJHID 2011.pdf (1.42 MB)

High Serum Erythropoietin and Ferritin Levels in Conjunction with Anemia Response in Malignant Lymphoma

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posted on 2023-05-17, 10:16 authored by Omari, SAM, Alhossain Khalafallah, Ayesh, M, Matalka, I, Al-Hadithi, R
Anemia is a common finding in lymphoma. There are few data available regarding the erythropoietin (EPO) levels in conjunction with ferritin in lymphoma patients. We prospectively evaluated 55 patients diagnosed with malignant lymphoma during the period between November 2006 and March 2008 at the King Abdullah University Teaching Hospital, Jordan. Our data showed that 74.4% of lymphoma patients were anemic. Furthermore, serum EPO and ferritin levels were higher in lymphoma patients compared with the healthy controls (P=0.001). The observed versus predicted EPO ratio showed also significantly higher levels in anemic lymphoma patients compared to healthy controls (p=0.03). There was an improvement in the Hb level in lymphoma patients who were treated with at least 3-cycles of chemotherapy as compared with newly-diagnosed patients. An adequate increase of EPO levels was observed in anemic lymphoma patients and notably associated with higher ferritin levels and improvement of Hb (p<0.001).Our findings suggest that ferritin estimation in lymphoma patients may predict the level of erythropoiesis and possibly the degree of anemia. Further studies to confirm these findings are warranted.

History

Publication title

Mediterranean Journal of Hematology and Infectious Diseases

Article number

e2011018

Number

e2011018

Pagination

1-5

ISSN

2035-3006

Department/School

School of Health Sciences

Publisher

Universita Cattolica del Sacro Cuore Istituto di Ematologia

Place of publication

Italy

Rights statement

Licensed under Creative Commons Attribution 2.0 Generic (CC BY 2.0) http://creativecommons.org/licenses/by/2.0/

Repository Status

  • Open

Socio-economic Objectives

Clinical health not elsewhere classified

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