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Pilot Study of Nebulised Morphine for Dyspnoea in Palliative Care Patients


Peterson, GM and Young, R and Dunne, P and Galloway, G and Parks, T, Pilot Study of Nebulised Morphine for Dyspnoea in Palliative Care Patients, Australian Journal of Hospital Pharmacy, 26, (5) pp. 545-547. ISSN 0310-6810 (1996) [Non Refereed Article]

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Copyrights 1999 Society of Hospital Pharmacists of Australia

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Objective: To investigate the efficacy of nebulised morphine for dyspnoea in a controlled trial involving eight terminally ill patients. Method: Over three consecutive days, patients received treatment for one day with four nebulised doses of either sodium chloride 0.9%, morphine 2.5 mg or morphine 5 mg. Both subjective severity of dyspnoea and respiratory function were monitored with each treatment. Results: Analysis of variance indicated that there was a statistically significant difference in the subjective symptoms of dyspnoea and respiratory function between individual patients. However, there was no evidence of any beneficial effects of nebulised morphine or saline in these patients, who were all receiving regular morphine by either the oral or subcutaneous route. Conclusion: This small trial suggests that there would be limited value in adding nebulised morphine, at the dosage studied, to oral or subcutaneous therapy in palliative care patients with dyspnoea.

Item Details

Item Type:Non Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:Young, R (Dr Rosemary Young)
ID Code:7493
Year Published:1996
Deposited By:Pharmacy
Deposited On:1996-08-01
Last Modified:2014-08-28
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