University of Tasmania
Browse

File(s) not publicly available

Irbesartan is projected to be cost and life saving in a Spanish setting for treatment of patients with type 2 diabetes, hypertension, and microalbuminuria

journal contribution
posted on 2023-05-17, 09:28 authored by Andrew PalmerAndrew Palmer, Annemans, L, Roze, S, Lapuerta, P, Chen, R, Gabriel, S, Carita, P, Rodby, RA, de Zeeuw, D, Parving, HH, De Alvaro, F
Objectives. The purpose of this study was to project the cumulative incidence of end-stage renal disease (ESRD), life expectancy, and costs in a Spanish setting of treating patients with diabetes, hypertension, and microalbuminuria with either standard hypertension treatment alone or standard hypertension treatment plus irbesartan 300 mg daily. Methods. A peer-reviewed, published Markov model that simulated progression from microalbuminuria to nephropathy, doubling of serum creatinine, ESRD, and all-cause mortality in patients with hypertension, type 2 diabetes, and microalbuminuria was adapted to a Spanish setting. Two strategies were compared: (1) irbesartan versus (2) standard hypertension care with comparable blood pressure control; both began in diabetic hypertensive subjects with microalbuminuria. Cumulative incidence of ESRD, costs, and life expectancy were projected for a hypothetical cohort of 1000 subjects. Future costs and life expectancy were discounted at 3% yearly. A 25-year time horizon and third party payer perspective were used. Results. When compared to standard blood pressure control, irbesartan was projected to reduce the cumulative incidence of ESRD from (mean ± standard deviation) 24 ± 1% to 9 ± 2%, save €11,082 ± 2,996, and add 1.40 ± 0.27 life years per treated patient. The superiority of irbesartan over standard care was robust under a wide range of plausible assumptions. Conclusion. Treating patients with hypertension, microalbuminuria, and type 2 diabetes with irbesartan was projected to reduce the incidence of ESRD, extend life, and reduce costs.

History

Publication title

Kidney International

Volume

67

Issue

Supplement 93

Pagination

S52-S54

ISSN

0085-2538

Department/School

Menzies Institute for Medical Research

Publisher

Blackwell Publishing Inc

Place of publication

350 Main St, Malden, USA, Ma, 02148

Repository Status

  • Restricted

Socio-economic Objectives

Evaluation of health and support services not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC