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Dried Blood Spot Sampling - A New Approach for Whole Blood Analysis

journal contribution
posted on 2023-05-22, 01:58 authored by Emily HilderEmily Hilder
Dried blood spot sampling (DBS) and analysis is a relatively simple process involving the collection of a very small sample of blood from either a finger, heel, or tail prick. This blood is then spotted on a filter paper and allowed to dry at room temperature for up to 2 h. The advantages of using DBS instead of plasma include using smaller blood volumes, less sample processing, improved sample stability in some cases, and samples do not need to be stored or shipped at low temperatures. Decreasing the size of blood samples collected offers substantial benefits for bioanalysis including reducing the use of animals in pharmacokinetic and toxicology studies and less invasive sampling with specific benefits for particular patient groups including the elderly, very young and critically ill. A particular advantage of this technology is that polymer monoliths can be easily functionalized using a range of approaches.

Funding

Pfizer

History

Publication title

Australian Journal of Chemistry

Volume

64

Issue

6

Pagination

843-843

ISSN

0004-9425

Department/School

School of Natural Sciences

Publisher

C S I R O Publishing

Place of publication

150 Oxford St, Po Box 1139, Collingwood, Australia, Victoria, 3066

Rights statement

Copyright © 2011 CSIRO

Repository Status

  • Restricted

Socio-economic Objectives

Expanding knowledge in the chemical sciences

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    University Of Tasmania

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