University of Tasmania
Browse

File(s) under permanent embargo

The effect of exercise on large artery haemodynamics in cystic fibrosis

journal contribution
posted on 2023-05-17, 06:44 authored by Hull, JH, Ansley, L, Bolton, CE, James SharmanJames Sharman, Knight, RK, Cockcroft, JR, Shale, DJ, Garrod, R
Background Adult patients with cystic fibrosis (CF) have resting abnormal large artery haemodynamics. Here, we obtain further insight in patients with CF by evaluating haemodynamic response to physiological stress. Methods Thirty-six stable CF patients mean (SD) age 28.9 (9.0) years and 25 controls matched for age, gender and body mass index were studied. Central haemodynamic parameters; including augmentation index (AIx) and wasted left ventricular pressure energy (∆EW) were determined pre, during and post light intensity cycle ergometry. Results During exercise, despite a similar heart rate and blood pressure, patients had comparatively greater ∆EW (P = 0.03) and trend towards greater AIx (P = 0.07) than controls. Exercise ∆EW was greatest in patients with CF related diabetes (n = 11). In all subjects, exercise ∆EW was related to age (r = 0.54, P < 0.001) and FEV1% predicted (r = − 0.32, P = 0.01). Conclusions Adults with CF have an abnormal haemodynamic response to exercise. This finding has deleterious implications for myocardial performance.

History

Publication title

Journal of Cystic Fibrosis

Volume

10

Pagination

121-127

ISSN

1569-1993

Department/School

Menzies Institute for Medical Research

Publisher

Elsevier BV

Place of publication

Netherlands

Rights statement

The definitive version is available at http://www.sciencedirect.com

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

Usage metrics

    University Of Tasmania

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC