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ER stress and the unfolded protein response in intestinal inflammation

journal contribution
posted on 2023-05-17, 05:00 authored by McGuckin, MA, Rajaraman Eri, Das, I, Lourie, R, Florin, TH
Endoplasmic reticulum (ER) stress is a phenomenon that occurs when excessive protein misfolding occurs during biosynthesis. ER stress triggers a series of signaling and transcriptional events known as the unfolded protein response (UPR). The UPR attempts to restore homeostasis in the ER but if unsuccessful can trigger apoptosis in the stressed cells and local inflammation. Intestinal secretory cells are susceptible to ER stress because they produce large amounts of complex proteins for secretion, most of which are involved in mucosal defense. This review focuses on ER stress in intestinal secretory cells and describes how increased protein misfolding could occur in these cells, the process of degradation of misfolded proteins, the major molecular elements of the UPR pathway, and links between the UPR and inflammation. Evidence is reviewed from mouse models and human inflammatory bowel diseases that ties ER stress and activation of the UPR with intestinal inflammation, and possible therapeutic approaches to ameliorate ER stress are discussed. Copyright © 2010 the American Physiological Society.

History

Publication title

American Journal of Physiology: Gastrointestinal and Liver Physiology

Volume

298

Issue

6

Pagination

G820-G832

ISSN

0193-1857

Department/School

School of Health Sciences

Publisher

American Physiological Society

Place of publication

USA

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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