eCite Digital Repository

Differential response to resistance training in CHF according to ACE genotype


Williams, AD and Anderson, MJ and Selig, S and Carey, MF and Febbraio, MA and Hayes, A and Toia, D and Harrap, SB and Hare, DL, Differential response to resistance training in CHF according to ACE genotype, International Journal of Cardiology, 149, (3) pp. 330-334. ISSN 0167-5273 (2011) [Refereed Article]

Restricted - Request a copy

Copyright Statement

The definitive version is available at

DOI: doi:10.1016/j.ijcard.2010.02.012


BACKGROUND: The Angiotensin Converting Enzyme (ACE) gene may influence the risk of heart disease and the response to various forms of exercise training may be at least partly dependent on the ACE genotype. We aimed to determine the effect of ACE genotype on the response to moderate intensity circuit resistance training in chronic heart failure (CHF) patients. METHODS: The relationship between ACE genotype and the response to 11weeks of resistance exercise training was determined in 37 CHF patients (New York Heart Association Functional Class=2.30.5; left ventricular ejection fraction 287%; age 6412years; 32:5 male:female) who were randomised to either resistance exercise (n=19) or inactive control group (n=18). Outcome measures included VO(2peak), peak power output and muscle strength and endurance. ACE genotype was determined using standard methods. RESULTS: At baseline, patients who were homozygous for the I allele had higher VO(2peak) (p=0.02) and peak power (p=0.003) compared to patients who were homozygous for the D allele. Patients with the D allele, who were randomised to resistance training, compared to non-exercising controls, had greater peak power increases (ID p<0.001; DD p<0.001) when compared with patients homozygous for the I allele, who did not improve. No significant genotype-dependent changes were observed in VO(2peak), muscle strength, muscle endurance or lactate threshold. CONCLUSION: ACE genotype may have a role in exercise tolerance in CHF and could also influence the effectiveness of resistance training in this condition.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Sports science and exercise
Research Field:Exercise physiology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Williams, AD (Associate Professor Andrew Williams)
ID Code:65425
Year Published:2011
Web of Science® Times Cited:8
Deposited By:Health Sciences A
Deposited On:2010-11-15
Last Modified:2017-10-30

Repository Staff Only: item control page