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Presenilins and the gamma-secretase: still a complex problem


Small, DH and Klaver, DW and Foa, L, Presenilins and the gamma-secretase: still a complex problem, Molecular Brain, 3, (1) pp. 1-6. ISSN 1756-6606 (2010) [Refereed Article]


Copyright Statement

© 2010 Small et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

DOI: doi:10.1186/1756-6606-3-7


The presenilins form part of a complex of membrane proteins that are involved in the proteolytic cleavage of cellsurface molecules. This article reviews the history of the discovery of the presenilins, their role in the pathogenesis of Alzheimer’s disease and in the metabolism of the amyloid-b precursor protein. Unanswered questions about their biochemical mechanism of action and their effects on Ca2+ homeostasis are examined.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Neurosciences not elsewhere classified
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Small, DH (Professor David Small)
UTAS Author:Klaver, DW (Mr David Klaver)
UTAS Author:Foa, L (Professor Lisa Foa)
ID Code:64854
Year Published:2010
Web of Science® Times Cited:21
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-09-07
Last Modified:2012-03-06
Downloads:321 View Download Statistics

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