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A new mechanistic pathway under Sonogashira reaction protocol involving multiple acetylene insertions
journal contribution
posted on 2023-05-17, 03:02 authored by Jones, RC, Allan CantyAllan Canty, Caradoc-Davies, T, Noel DaviesNoel Davies, Michael GardinerMichael Gardiner, Marriott, PJ, Ruehle, CPG, Tolhurst, VAn unreported product outcome from an intended Sonogashira coupling is presented. The generality of this finding has been demonstrated by screening of a range of pre-catalysts. Mechanistic studies are consistent with the tetra-aryl benzene product forming by interception of the aryl halide oxidative addition intermediate by repeated acetyleneinsertion.
History
Publication title
Dalton TransactionsVolume
39Issue
16Pagination
3799-3801ISSN
1477-9226Department/School
School of Natural SciencesPublisher
Royal Soc ChemistryPlace of publication
Thomas Graham House, Science Park, Milton Rd, Cambridge, England, Cambs, Cb4 0WfRights statement
Copyright © 2010 The Royal Society of ChemistryRepository Status
- Restricted