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Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus
journal contribution
posted on 2023-05-17, 03:00 authored by Miller, RD, Hogg, J, Ozaki, JH, David GellDavid Gell, Jackson, SP, Riblet, RThe gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PK(cs)) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PK(cs) to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PK(cs) does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PK(cs).
History
Publication title
National Academy of Sciences of The United States of America. ProceedingsVolume
92Issue
23Pagination
10792-10795ISSN
0027-8424Department/School
Menzies Institute for Medical ResearchPublisher
Natl Acad SciencesPlace of publication
2101 Constitution Ave Nw, Washington, USA, Dc, 20418Repository Status
- Restricted