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Probing the kinetic performance limits for ion chromatography. II. Gradient conditions for small ions


Causon, TJ and Hilder, EF and Shellie, RA and Haddad, PR, Probing the kinetic performance limits for ion chromatography. II. Gradient conditions for small ions, The Journal of Chromatography A, 1217, (31) pp. 5063-5068. ISSN 0021-9673 (2010) [Refereed Article]

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DOI: doi:10.1016/j.chroma.2010.05.002


A gradient kinetic plot method is used for theoretical characterisation of the performance of polymeric particulate anion exchange columns for gradient separations of small inorganic anions. The method employed requires only information obtained from a series of isocratic column performance measurements and in silico predictions of retention time and peak width under gradient conditions. Results obtained under practically constrained conditions provide parameters for the generation of high peak capacities and rapid peak production for fast analysis to be determined. Using this prediction method, a maximum theoretical peak capacity of 84 could be used to achieve separation of 26 components using a 120 min gradient (Rs > 1). This approach provides a highly convenient tool for development of both mono- and multidimensional ion chromatography (IC) methodologies as it yields comprehensive understanding of the influence of gradient slope, analysis time, column length and temperature upon kinetically optimised gradient performance.

Item Details

Item Type:Refereed Article
Keywords:Ion-exchange; Ion chromatography; Kinetic performance; Gradient
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Causon, TJ (Mr Timothy Causon)
UTAS Author:Hilder, EF (Professor Emily Hilder)
UTAS Author:Shellie, RA (Associate Professor Robert Shellie)
UTAS Author:Haddad, PR (Professor Paul Haddad)
ID Code:64329
Year Published:2010
Funding Support:Australian Research Council (DP0663781)
Web of Science® Times Cited:15
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2010-07-16
Last Modified:2014-11-21

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