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Plasma brominated polymer particles as grafting substrate for thiol-terminated telomers


Bystrom, E and Nordborg, A and Lime, F and Dinh, NP and Irgum, K, Plasma brominated polymer particles as grafting substrate for thiol-terminated telomers, Journal of Separation Science, 33, (11) pp. 1563-1570. ISSN 1615-9306 (2010) [Refereed Article]

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DOI: doi:10.1002/jssc.201000028


A combined surface activation and grafting to strategy was developed to convert divinylbenzene particles into weak cation exchangers suitable for protein separation. The initial activation step was based on plasma modification with bromoform, which rendered the particles amenable to further reaction with nucleophiles by introducing Br to a surface content of 11.2 atom-%, as determined by X-ray photoelectron spectroscopy. Grafting of thiol-terminated glydicyl methacrylate telomers to freshly plasma activated surfaces was accomplished without the use of added initiator, and the grafting was verified both by reduction in bromine content and the appearance of sulfur-carbon linkages, showing that the surface grafts were covalently bonded. Following grafting the attached glydicyl methacrylate telomer tentacles were further modified by a two-step procedure involving hydrolysis to 2,3-hydroxypropyl groups and conversion of hydroxyl groups to carboxylate functionality by succinic anhydride. The final material was capable of baseline separating four model proteins in 3 min by gradient cation exchange chromatography in a fully aqueous eluent.

Item Details

Item Type:Refereed Article
Keywords:Grafting to • Non-porous divinylbenzene particles • Plasma bromination • Precipitation polymerization • Telomer surface modification
Research Division:Chemical Sciences
Research Group:Analytical chemistry
Research Field:Separation science
Objective Division:Expanding Knowledge
Objective Group:Expanding knowledge
Objective Field:Expanding knowledge in the chemical sciences
UTAS Author:Nordborg, A (Dr Anna Nordborg)
ID Code:63731
Year Published:2010
Web of Science® Times Cited:5
Deposited By:Austn Centre for Research in Separation Science
Deposited On:2010-05-26
Last Modified:2011-05-04
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