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Genetic association between GHSR1a 5'UTR-microsatellite and nt-7 (C>A) loci and growth and carcass traits in Japanese Black cattle
journal contribution
posted on 2023-05-17, 02:33 authored by Komatsu, M, Itoh, T, Fujimori, Y, Satoh, M, Miyazaki, Y, Takahashi, H, Shimizu, K, Malau-Aduli, AEO, Morita, MWe carried out a genetic association study between five nucleotide polymorphisms (5ŒUTR microsatellite ((TG)n), nt-7(C>A), L24V, DelR242 and Intron 1 microsatellite) of the GHSR1a gene and growth and carcass traits in 1285 steers sired by 117 Japanese Black bulls in a progeny testing program. We report herein, a significant association between the 5ŒUTR microsatellite and nt-7(C>A) loci and growth and carcass traits. We also propose a translational hypothesis that the association is due to differences in the secondary structure of GHSR1b mRNA (the non-spliced type with the 5ŒUTR microsatellite) among the GHSR1a gene haplotypes. Furthermore, we predicted the potential increase in profitability due to increased carcass weight in cow-calf fattening enterprises through planned matings based on DNA testing of the 5ŒUTR microsatellite. Statistical analysis revealed that the 5ŒUTR microsatellite locus had a significant additive effect on carcass weight (CW) and average daily gain (ADG), but not on beef marbling score (BMS). One of the four major microsatellite alleles (19-TG allele) with an allele frequency of 0.145, had a significantly (P < 0.0007) desirable effect on CW and ADG. We concluded that the 19-TG allele could potentially be economically useful nucleotide markers for growth and carcass traits in Japanese Black cattle
History
Publication title
Animal Science JournalVolume
82Pagination
396-405ISSN
1344-3941Department/School
Tasmanian Institute of Agriculture (TIA)Publisher
Wiley-Blackwell Publishing AsiaPlace of publication
AustraliaRights statement
The definitive published version is available online at: http://onlinelibrary.wiley.com/Repository Status
- Restricted