File(s) not publicly available
Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons
journal contribution
posted on 2023-05-17, 01:43 authored by Koh, CH, Whiteman, M, Li, QX, Halliwell, B, Jenner, AM, Wong, BS, Laughton, KM, Wenk, M, Masters, CL, Beart, PM, Bernard, O, Cheung, NSFindings that antioxidant treatment may be beneficial in Alzheimer's disease indicate that oxidative stress is an important factor in its pathogenesis. Studies have also suggested that cholesterol imbalance in the brain might be related to the development of neurological disorders. Previously, we have reported that U18666A, a cholesterol transport-inhibiting agent, leads to apoptosis and intracellular cholesterol accumulation in primary cortical neurons. In this study, we found that neuronal apoptosis mediated by U18666A is associated with oxidative stress in the treated cortical neurons. Cortical neurons treated with U18666A also showed decreased secretion and increased intraneuronal accumulation of â-a-myloid. The association of neuronal apoptosis with oxidative stress and Aâ accumulation may provide clues to the pathogenesis of Alzheimer's disease, as well as the role oxidative stress plays in other neurodegenerative diseases.
History
Publication title
Journal of NeurochemistryVolume
98Issue
4Pagination
1278-1289ISSN
0022-3042Department/School
Menzies Institute for Medical ResearchPublisher
Blackwell Publishing LtdPlace of publication
9600 Garsington Rd, Oxford, England, Oxon, Ox4 2DgRepository Status
- Restricted