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Relationship between homocysteine and cardiorespiratory fitness is sex-dependent


Coombes, JS and Fraser, DI and Sharman, JE and Booth, C, Relationship between homocysteine and cardiorespiratory fitness is sex-dependent, Nutrition Research: The International Medium for Rapid Publication of Communications in The Nutritional Sciences, 24, (8) pp. 593-602. ISSN 0271-5317 (2004) [Refereed Article]

DOI: doi:10.1016/j.nutres.2003.11.015


Elevated plasma homocysteine is recognized as an independent risk factor for cardiovascular disease. Recently, there have been conflicting reports of the relationship between physical activity and homocysteine. A more objective measure of physical activity is cardiorespiratory fitness; however, its relationship with homocysteine has yet to be investigated. The aim of this study was to determine the relationship between cardiorespiratory fitness and plasma homocysteine. Cross-sectional associations between cardiorespiratory fitness (VO2max) and plasma homocysteine were examined in 49 men and 11 women. A submaximal bicycle test was used to determine VO2max and plasma homocysteine was measured using high performance liquid chromatography with fluorescence detection. Dietary analysis determined B vitamin intake. There was a significant inverse relationship between plasma homocysteine concentration and VO2max in women (r = -0.81, P = 0.003) but not in men (r = -0.09, P = 0.95). There were no significant relationships between plasma homocysteine and age, BMI, body fat, total cholesterol, and LDL cholesterol. In summary, elevated cardiorespiratory fitness is associated with decreased plasma homocysteine concentrations in women.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Cardiovascular medicine and haematology
Research Field:Cardiology (incl. cardiovascular diseases)
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Sharman, JE (Professor James Sharman)
ID Code:61339
Year Published:2004
Web of Science® Times Cited:1
Deposited By:Menzies Institute for Medical Research
Deposited On:2010-03-02
Last Modified:2010-05-03

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