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Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13


Teh, BT and Cardinal, J and Shepherd, JJ and Hayward, N and Weber, G and Cameron, D and Larsson, C, Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13, Journal of Internal Medicine, 238, (3) pp. 249-253. ISSN 0954-6820 (1995) [Refereed Article]

DOI: doi:10.1111/j.1365-2796.1995.tb00931.x


Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is associated with somatic deletions involving the MEN1 locus at chromosomal region 11q13, suggesting inactivation of a tumour-suppressor gene in this region. Here we describe the localization of the MEN1 gene to a 900-kb region, based on linkage analysis in affected families and deletion mapping of MEN1-associated tumours. In addition, a set of microsatellite markers mapped to the 11q11-13 region were used for linkage analysis in a large Tasmanian MEN1 pedigree, demonstrating the usefulness of these markers for presymptomatic testing in affected families.

Item Details

Item Type:Refereed Article
Research Division:Biological Sciences
Research Group:Genetics
Research Field:Gene expression (incl. microarray and other genome-wide approaches)
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Shepherd, JJ (Professor Joseph Shepherd)
ID Code:6058
Year Published:1995
Web of Science® Times Cited:15
Deposited By:Surgery
Deposited On:1995-08-01
Last Modified:2011-08-25

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