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Inactivation of retinoblastoma gene in malignant parathyroid growths - A candidate genetic trigger


Subramaniam, P and Wilkinson, SJ and Shepherd, JJ, Inactivation of retinoblastoma gene in malignant parathyroid growths - A candidate genetic trigger, The Australian and New Zealand Journal of Surgery, 65, (10) pp. 714-716. ISSN 0004-8682 (1995) [Refereed Article]

DOI: doi:10.1111/j.1445-2197.1995.tb00542.x


The molecular basis for parathyroid carcinoma remains undetermined. Parathyroid carcinoma potentially remains curable by early en bloc resection. This requires a reliable diagnostic tool as histological features alone are insufficient to distinguish parathyroid carcinoma from its benign counterpart, parathyroid adenoma. A variety of human cancers arise from the inactivation of the retinoblastoma (RB) gene, a tumour-suppressor gene on chromosome 13q14. We investigated the role of this gene parathyroid growths by using a mouse monoclonal antibody to detect RB gene expression immunohistochemically. Two of the three parathyroid carcinomas in this study showed evidence of RB gene inactivation compared with one of 11 benign parathyroid entities. Three normal parathyroid glands stained showed strong evidence of RB gene expression in all three glands. The relationship between RB gene inactivation and parathyroid malignancy, however, was not statistically significant.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Medical biotechnology
Research Field:Medical biotechnology not elsewhere classified
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Subramaniam, P ( Subramaniam)
UTAS Author:Wilkinson, SJ (Dr Stephen Wilkinson)
UTAS Author:Shepherd, JJ (Professor Joseph Shepherd)
ID Code:6024
Year Published:1995
Web of Science® Times Cited:19
Deposited By:Surgery
Deposited On:1995-08-01
Last Modified:2011-08-25

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