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Correlates of Subchondral BMD: A Cross-Sectional Study

journal contribution
posted on 2023-05-17, 00:56 authored by Dawn AitkenDawn Aitken, Quinn, S, Chang-Hai DingChang-Hai Ding, Tania WinzenbergTania Winzenberg, Graeme JonesGraeme Jones
Subchondral bone is hypothesized to be important in the development and progression of osteoarthritis (OA); however, little is known about the determinants of subchondral bone. This study describes the relationship between tibial subchondral BMD (sBMD) and anthropometric, lifestyle, and structural measures in 740 randomly selected subjects (mean age, 62 yr; range, 50–80 yr; 52% women). We measured medial tibial sBMD by DXA at two regions of interest (ROIs). We also assessed anthropometrics, vitamin D, steps per day by pedometer, joint space narrowing (JSN) and osteophytes (by X-ray), cartilage defects, cartilage volume, and bone marrow lesions (BML; by MRI), and hip and spine BMD (by DXA). sBMD using ROI 1 was negatively associated with age and female sex and positively associated with BMI. In multivariable analysis, sBMD was positively correlated with steps per day (r = 0.08, p = 0.025), tibial osteophytes (r = 0.08, p = 0.028), JSN (r = 0.11, p < 0.01), cartilage defects (r = 0.16, p < 0.01), cartilage volume (r = 0.12, p = 0.01), BMLs (r = 0.17, p = 0.013 [tibial]; r = 0.16, p = 0.018 [femoral]), and hip and spine BMD (r = 0.36, p < 0.01 and r = 0.38, p < 0.01, respectively). Similar associations were observed using ROI 2, with vitaminDalso associated with sBMD (r = 0.10, p < 0.01). In conclusion, this study identified a large number of factors associated with sBMD, of which the most novel is cartilage defects. Longitudinal studies are required to address causality.

History

Publication title

Journal of Bone and Mineral Research

Volume

24

Issue

12

Pagination

2007-2015

ISSN

0884-0431

Department/School

Menzies Institute for Medical Research

Publisher

Amer Soc Bone & Mineral Res

Place of publication

2025 M St, N W, Ste 800, Washington, USA, Dc, 20036-3309

Repository Status

  • Restricted

Socio-economic Objectives

Clinical health not elsewhere classified

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