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Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging


Woodhouse, A and Vickers, JC and Adlard, PA and Dickson, TC, Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging, Neurobiology of Aging, 30, (6) pp. 864-874. ISSN 0197-4580 (2009) [Refereed Article]

DOI: doi:10.1016/j.neurobiolaging.2007.09.003


The morphology and neurochemistry of β-amyloid (Aβ) plaque-associated dystrophic neurites present in TgCRND8 and Tg2576 mice was demonstrated to be strikingly similar to that observed in pathologically aged human cases, but not in Alzheimer’s disease (AD) cases. Specifically, pathologically aged cases and both transgenic mouse lines exhibited a-internexin- and neurofilament-triplet-labelled ring- and bulb-like dystrophic neurites, but no classical hyperphosphorylated-tau dystrophic neurite pathology. In contrast, AD cases demonstrated abundant classical hyperphosphorylated-tau-labelled dystrophic neurites, but no neurofilament-triplet-labelled ring-like dystrophic neurites. Importantly, quantitation demonstrated that the Aβ plaques in TgCRND8 mice were highly axonopathic, and localised displacement or clipping of apical dendrite segments was also associated with AB plaques in both transgenic mouse models. These results suggest that neuronal pathology in these mice represent an accurate and valuable model for understanding, and developing treatments for, the early brain changes of AD.

Item Details

Item Type:Refereed Article
Keywords:dystrophic neurites, hyperphosphorylated-tau, alpha-internexin, neurofilament; TgCRND8, Tg2576, preclinical Alzheimer’s disease, pathological aging
Research Division:Biomedical and Clinical Sciences
Research Group:Neurosciences
Research Field:Central nervous system
Objective Division:Health
Objective Group:Clinical health
Objective Field:Clinical health not elsewhere classified
UTAS Author:Woodhouse, A (Dr Adele Woodhouse)
UTAS Author:Vickers, JC (Professor James Vickers)
UTAS Author:Dickson, TC (Professor Tracey Dickson)
ID Code:59225
Year Published:2009
Web of Science® Times Cited:30
Deposited By:Menzies Institute for Medical Research
Deposited On:2009-11-26
Last Modified:2013-11-15

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