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Plasma concentrations of fentanyl with subcutaneous infusion in palliative care patients


Miller, RS and Peterson, GM and Abbott, F and Maddocks, I and Parker, D and McLean, SR, Plasma concentrations of fentanyl with subcutaneous infusion in palliative care patients, British Journal of Clinical Pharmacology, 40, (6) pp. 553 - 556. ISSN 0306-5251 (1995) [Refereed Article]

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Plasma concentrations of fentanyl were measured by g.c. in 20 patients (median age: 75 years and range: 54-86 years; eight females) in palliative care receiving the drug by continuous s.c. infusion (median rate: 1200 micrograms day-1 and range: 100-5000 micrograms day-1). 2. The infusion rate was significantly related to the duration of therapy (Spearman rho = 0.56, P < 0.05). The total steady-state plasma concentrations of fentanyl ranged between 0.1 and 9 ng ml-1, with a median of 1 ng ml-1. The unbound fraction of fentanyl in the plasma ranged from 17.8 to 44.4%, with a median value of 33.6%. Infusion rates and both total and unbound plasma concentrations of fentanyl were correlated (Spearman rho = 0.92, P < 0.05 in each case). Even with standardization for dosage, there was an eightfold variation in total plasma concentrations and 3.5-fold variation in unbound plasma concentrations of fentanyl. 3. There is considerable inter-patient variability in the pharmacokinetics of fentanyl with s.c. infusion in the palliative care setting, which necessitates careful titration of dosage according to individual clinical response.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Miller, RS (Mrs Rachel Susan Miller)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
UTAS Author:McLean, SR (Professor Stuart McLean)
ID Code:5377
Year Published:1995
Web of Science® Times Cited:12
Deposited By:Pharmacy
Deposited On:1995-08-01
Last Modified:2011-06-02

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