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Amnesia following gastroscopy with midazolam - comparison in 2 age groups

journal contribution
posted on 2023-05-16, 09:48 authored by Kenneth KirkbyKenneth Kirkby, Scarcia, MJ, Montgomery, IM, Daniels, BA
Forty patients, in two age groups, undergoing gastroscopy, received intravenous midazolam as the sole pre- medication. Mean ages were 35 (range 19-47) and 65.5 (range 53-75) and mean dosages 4.52 and 5.82 mg, respectively in the two groups. Neuropsychological testing pre- and post-medication comprised the Rey auditory verbal learning test (RAVLT), word association test, digit span and face memory test. The elderly group gave significantly more false-positive responses on recognition recall on the RAVLT and had significant impairment of reverse digit span. Following midazolam, in both age groups there was a significantly reduced rate of verbal learning and a marked deficit in delayed free recall coupled with substantial preservation of recognition recall. Word fluency and forward digit span were not affected. There was an increase in false-positive responses for face memory. These findings are consistent with a specific processing deficit affecting the acquisition of episodic long-term memory. © 1995, Sage Publications. All rights reserved.

History

Publication title

Journal of Psychopharmacology

Volume

9

Pagination

32-37

ISSN

0269-8811

Department/School

Tasmanian School of Medicine

Publisher

Sage Publications Ltd

Place of publication

Oxford

Repository Status

  • Restricted

Socio-economic Objectives

Other health not elsewhere classified

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