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Amnesia following gastroscopy with midazolam - comparison in 2 age groups


Kirkby, KC and Scarcia, MJ and Montgomery, IM and Daniels, BA, Amnesia following gastroscopy with midazolam - comparison in 2 age groups, Journal of Psychopharmacology, 9, (1) pp. 32-37. ISSN 0269-8811 (1995) [Refereed Article]

DOI: doi:10.1177/026988119500900106


Forty patients, in two age groups, undergoing gastroscopy, received intravenous midazolam as the sole pre- medication. Mean ages were 35 (range 19-47) and 65.5 (range 53-75) and mean dosages 4.52 and 5.82 mg, respectively in the two groups. Neuropsychological testing pre- and post-medication comprised the Rey auditory verbal learning test (RAVLT), word association test, digit span and face memory test. The elderly group gave significantly more false-positive responses on recognition recall on the RAVLT and had significant impairment of reverse digit span. Following midazolam, in both age groups there was a significantly reduced rate of verbal learning and a marked deficit in delayed free recall coupled with substantial preservation of recognition recall. Word fluency and forward digit span were not affected. There was an increase in false-positive responses for face memory. These findings are consistent with a specific processing deficit affecting the acquisition of episodic long-term memory. © 1995, Sage Publications. All rights reserved.

Item Details

Item Type:Refereed Article
Research Division:Health Sciences
Research Group:Health services and systems
Research Field:Mental health services
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Kirkby, KC (Professor Kenneth Kirkby)
UTAS Author:Scarcia, MJ (Dr Maria Scarcia)
UTAS Author:Montgomery, IM (Dr Iain Montgomery)
UTAS Author:Daniels, BA (Dr Brett Daniels)
ID Code:4871
Year Published:1995
Web of Science® Times Cited:4
Deposited By:Clinical Sciences
Deposited On:1995-08-01
Last Modified:2011-08-24

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