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Stability of ipratropium bromide and salbutamol nebuliser admixtures


Jacobson, GA and Peterson, GM, Stability of ipratropium bromide and salbutamol nebuliser admixtures, International Journal of Pharmacy Practice, 3, (3) pp. 169-173. ISSN 2042-7174 (1995) [Refereed Article]

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DOI: doi:10.1111/j.2042-7174.1995.tb00812.x


The physicochemical stability of an admixture of ipratropium bromide and salbutamol nebuliser solutions, 1:1 v/v, was determined by storing solutions for five days in a refrigerator at 4C, at 22C protected from light and at 22C under 24 hour fluorescent lighting. Concentrations of ipratropium and salbutamol were periodically determined using a high performance liquid chromatography assay. The nebuliser solution admixtures retained greater than 90 per cent of their original concentrations of ipratropium and salbutamol for the duration of the study. Differences in losses between storage conditions were not statistically significant. Admixtures of proprietary ipratropium bromide and salbutamol nebuliser solutions (1:1 v/v) retain greater than 90 per cent of their initial concentrations if stored between 4C and 22C for periods of up to five days. An expiry period of five days for these admixtures would seem reasonable in practice.

Item Details

Item Type:Refereed Article
Research Division:Biomedical and Clinical Sciences
Research Group:Pharmacology and pharmaceutical sciences
Research Field:Clinical pharmacology and therapeutics
Objective Division:Health
Objective Group:Other health
Objective Field:Other health not elsewhere classified
UTAS Author:Jacobson, GA (Associate Professor Glenn Jacobson)
UTAS Author:Peterson, GM (Professor Gregory Peterson)
ID Code:4730
Year Published:1995
Deposited By:Pharmacy
Deposited On:1995-08-01
Last Modified:2011-06-02
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