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Treatment with the thiazolidinedione (BRL 49653) decreases insulin resistance in obese Zucker hindlimb

journal contribution
posted on 2023-05-16, 09:42 authored by Eldershaw, TPD, Stephen RattiganStephen Rattigan, Cawthorne, MA, Buckingham, RE, Colquhoun, EQ, Michael ClarkMichael Clark
Hindlimbs of mature age obese fa/fa Zucker rats were perfused and found to be markedly insulin-resistant when compared to the hindlimbs of age-matched lean Fa/? animals. Hindlimb analysis also showed a greater content of fat and a lower content of muscle in the obese. Treatment of the obese animals for 7 days with the thiazolidinedione, BRL 49653 (3 μmol/kg/day) significantly decreased the insulin resistance of the hindlimb and significantly increased the rate of weight gain in the whole rat. However, the decreased insulin resistance due to BRL 49653 could not be accounted for by an increase in the proportion of hindlimb muscle to fat or by an increase in the hindlimb muscle mass perfused.

History

Publication title

Hormone and Metabolic Research

Volume

27

Issue

4

Pagination

169-172

ISSN

0018-5043

Department/School

Tasmanian School of Medicine

Publisher

Georg Thieme Verlag Kg

Place of publication

USA

Repository Status

  • Restricted

Socio-economic Objectives

Other health not elsewhere classified

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    University Of Tasmania

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