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Treatment with the thiazolidinedione (BRL 49653) decreases insulin resistance in obese Zucker hindlimb
journal contribution
posted on 2023-05-16, 09:42 authored by Eldershaw, TPD, Stephen RattiganStephen Rattigan, Cawthorne, MA, Buckingham, RE, Colquhoun, EQ, Michael ClarkMichael ClarkHindlimbs of mature age obese fa/fa Zucker rats were perfused and found to be markedly insulin-resistant when compared to the hindlimbs of age-matched lean Fa/? animals. Hindlimb analysis also showed a greater content of fat and a lower content of muscle in the obese. Treatment of the obese animals for 7 days with the thiazolidinedione, BRL 49653 (3 μmol/kg/day) significantly decreased the insulin resistance of the hindlimb and significantly increased the rate of weight gain in the whole rat. However, the decreased insulin resistance due to BRL 49653 could not be accounted for by an increase in the proportion of hindlimb muscle to fat or by an increase in the hindlimb muscle mass perfused.
History
Publication title
Hormone and Metabolic ResearchVolume
27Issue
4Pagination
169-172ISSN
0018-5043Department/School
Tasmanian School of MedicinePublisher
Georg Thieme Verlag KgPlace of publication
USARepository Status
- Restricted