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α-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the α-amyloid plaques in inducing neuronal injury
journal contribution
posted on 2023-05-16, 16:11 authored by Tracey DicksonTracey Dickson, Jyoti ChuckowreeJyoti Chuckowree, Meng Inn ChuahMeng Inn Chuah, Adrian WestAdrian West, James VickersJames VickersThis study investigated the role of α-internexin in the neuronal alterations associated with β-amyloid plaque formation in Alzheimer's disease (AD). Cortical neurons could be defined by their variable content of neurofilament (NF) triplet and α-internexin proteins, with a distinct population of supragranular pyramidal cells containing α-internexin alone. Both NF triplet and α-internexin were localized to reactive axonal structures in physically damaged neurons in experimental trauma models. Similarly, NF triplet and α-internexin immunoreactive neurites were localized to plaques densely packed with β-amyloid fibrils in preclinical AD cases, indicating that certain plaques may cause structural injury or impediment of local axonal transport. However, α-internexin, and not NF triplet, ring-like reactive neurites were present in end-stage AD cases, indicating the relatively late involvement of neurons that selectively contain α-internexin. These results implicate the expression of specific intermediate filament proteins in a distinct hierarchy of differential neuronal vulnerability to AD. © 2004 Elsevier Inc. All rights reserved.
History
Publication title
Neurobiology of DiseaseVolume
18Pagination
286-295ISSN
0969-9961Department/School
Tasmanian School of MedicinePublisher
Academic Press Inc, Alsevier SciencePlace of publication
San Diego, California, USARepository Status
- Restricted