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The scaffold protein, Homer 1b/c, regulates axon pathfinding in the central nervous system in vivo
journal contribution
posted on 2023-05-16, 15:27 authored by Lisa FoaLisa Foa, Rajan, I, Haas, K, Wu, G, Brakeman, P, Worley, P, Cline, HHomer proteins are a family of multidomain cytosolic proteins that have been postulated to serve as scaffold proteins that affect responses to extracellular signals by regulating protein-protein interactions. We tested whether Homer proteins are involved in axon pathfinding in vivo, by expressing both wild-type and mutant isoforms of Homer in Xenopus optic tectal neurons. Time-lapse imaging demonstrated that interfering with the ability of endogenous Homer to form protein-protein interactions resulted in axon pathfinding errors at stereotypical choice points. These data demonstrate a function for scaffold proteins such as Homer in axon guidance. Homer may facilitate signal transduction from cell-surface receptors to intracellular proteins that govern the establishment of axon trajectories.
History
Publication title
Nature NeuroscienceVolume
4Issue
5Pagination
499-506ISSN
1097-6256Department/School
Tasmanian School of MedicinePublisher
Nature Publishing GroupPlace of publication
New YorkRepository Status
- Restricted