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Dietary Microbial Toxins and Type 1 Diabetes
journal contribution
posted on 2023-05-16, 14:07 authored by Myers, MA, Hettiarachchi, K, Ludeman, J, Annabel WilsonAnnabel Wilson, Calum WilsonCalum Wilson, Zimmet, PZToxins may promote type 1 diabetes by modifying or damaging the β cell causing release of autoantigens. Streptomyces is a common soil bacterium that produces many toxic compounds. Some Streptomyces can infect vegetables, raising the possibility of dietary exposure to toxins. We aimed to identify toxins that erode cellular proton gradients in extracts of Streptomyces and infested vegetables and to establish the effect of low doses of these toxins on pancreatic islets in mice. The vacuolar ATPase inhibitors, bafilomycin and concanamycin, and the ionophore, nigericin, were identified in extracts from 4 of 13 Streptomyces isolated from infested potatoes and in potatoes themselves. Injection of bafilomycin A1 into mice impaired glucose tolerance, reduced islet size, and decreased relative β cell mass. Thus, exposure to small quantities of bafilomycin in the diet may contribute to the cause of type 1 diabetes.
History
Publication title
Annals of the New York Academy of ScienceVolume
1005Pagination
418-422ISSN
0077-8923Department/School
Tasmanian Institute of Agriculture (TIA)Publisher
New York Academy of SciencesPlace of publication
New York, USARepository Status
- Restricted