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Genetic resistance to smallpox: lessons from mousepox

Citation

Karupiah, G and Panchanathan, V and Sakala, IG and Chaudhri, G, Genetic resistance to smallpox: lessons from mousepox, Decoding the Genomic Control of Immune Reactions, Wiley, GR Bock and JA Goode (ed), United States, pp. 129-140. ISBN 978-0-470-02755-4 (2007) [Research Book Chapter]


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Copright 2007 Wiley

DOI: doi:10.1002/9780470062128.ch11

Abstract

There is increased interest in understanding protective immunity to smallpox for two principal reasons. First, it is the only disease that has been successfully eradicated using a live virus vaccine and, second, there exists a potential threat of intentional or unintentional release of variola virus, the causative agent of smallpox. Although mortality rates associated with smallpox were as high as 40%, a significant subset of those infected recovered. The basis of susceptibility or resistance, and the immune parameters associated with recovery, are still unknown. Animal models of poxvirus infections are being employed to understand what constitutes an effective host response. Ectromelia virus is closely related to variola virus and it causes a disease similar to smallpox in mice. This model is well established, resistant and susceptible strains of mice are defined and four genetic loci associated with resistance have been identified. Susceptibility to infec tion and disease severity is also influenced by virus immune evasion strategies. The outcome of infection is clearly dictated by several factors including host and viral genes, both of which influence the immune response. Here we present data on one virus-encoded immune modifier and its effect on the functions of two host genetic loci associ ated with resistance.

Item Details

Item Type:Research Book Chapter
Keywords:Poxvirus; genetic resistance to infection; ectromelia virus; variola virus
Research Division:Biomedical and Clinical Sciences
Research Group:Immunology
Research Field:Cellular immunology
Objective Division:Health
Objective Group:Clinical health
Objective Field:Prevention of human diseases and conditions
UTAS Author:Karupiah, G (Associate Professor Guna Karupiah)
ID Code:142924
Year Published:2007
Deposited By:Medicine
Deposited On:2021-02-16
Last Modified:2021-04-07
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